Diabetes and Its Risk of Amputation
A number of complications can be caused by diabetes in the human body and amongst these one happens to be neuropathy. In this type of condition, the nerves become inflamed and begin to degenerate resulting in poor blood circulation as well as nerve damage. Approximately 65% of the diabetic patients suffer from neuropathy which might result in tingling, numbness and also the loss of any feeling particularly in the feet and the legs. Once the sensation is lost in these parts of the body, ulcers and sores can form without the knowledge of the individual. Due to the hindrance of circulation, it is not possible for the wound to heal properly and in most cases, the situation becomes aggravated. There is a chance for the wound to become infected in case it is not treated immediately and the infection can even spread to the surrounding tissues. In this case, the only solution to fix the problem will be amputation.
What Is Invokana And How It Functions?
Invokana (Canagliflozin) is actually a medicine which is used for treating type II diabetes. The blood sugar of the patient can rise to unhealthy levels and most of the medicines treat this condition by simply pushing the sugar out of the bloodstream. The conventional insulin therapy functions by pushing the sugar from the bloodstream into the cells. This definitely helps to minimize the blood sugar level but only for a brief period of time. Unfortunately, cells might malfunction or even die eventually since it had been forced to absorb an excess quantity of sugar. In order to prevent this from taking place, the human body becomes more resistant to the insulin effects which results in an increase in the insulin doses and also increased storage of sugar in the cells where it doesn’t belong. Unfortunately, this can result in the death of tissues, metabolic disorders, nerve pain and also other complications.
Invokana is intended for preventing these conditions by excreting the excess sugar through urine. Hypothetically, it is not possible for the sugar to accumulate in the blood or in the cells in case it is evacuated from the human body. For doing this, the drug tries to change the way in which blood is filtered by the kidneys.
Usually, kidneys filter the blood in several stages. Eventually, the toxins are eliminated from the bloodstream and evacuated through urine. However, other necessary substances are going to be retained.
In one particular stage, the kidney is responsible for removing the sugar from our bloodstream and in another one this removal process is being fixed while the sugar goes back to the bloodstream. A naturally occurring ingredient known as sodium-glucose cotransporter 2 (SGLT2) is used in this method of replacing the sugar.
However, this element is being inhibited by Invokana. Consequently, the kidney is not able to put back all the sugar back into the bloodstream. This leads to a lower blood sugar level since the excess amount of sugar is being evacuated through urine. Hence, the issues related to long-term insulin therapy are also minimized to a large extent.
Invokana Might Result In Amputations:
According to FDA (U.S. Food and Drug Administration), Invokana enhances the danger of foot plus leg amputations in folks suffering from Type 2 diabetes.
It was revealed by the outcomes of a couple of clinical trials that the possibility of leg and foot amputations is about two times more in individuals using Invokana as compared to those using a placebo, as per a statement on the official website of FDA.
The health watchdog states that new notifications including its most significant Boxed Warning should be included on the medicine label.
One of the medical tests pointed out that, the threat of amputation in Invokana users during the course of one year was approximately 10 out of 1,000, in contrast to 2.7 out of 1,000 for those folks in the placebo category.
The other clinical test revealed that the danger of amputation was almost 8 out of every 1,000 individuals using Invokana, in contrast to 4.3 out of every 1,000 provided with a placebo.
Although the toe, as well as the middle of the foot, was amputated in most cases, amputations involving the leg plus above and below the knee also happened.
FDA has advised individuals using Invokana to get in touch with their medical care experts without any delay in case any discomfort or pain, sores or ulcers or infections are experienced by them in their feet or legs. However, patients must not quit using the medicine without taking the advice of their medical practitioner.
According to the FDA, prior to recommending Invokana for an individual suffering from Type 2 diabetes, it is imperative for the medical care providers to take into consideration whether that person has gone through any amputation in the past or is currently suffering from damaged nerves, in addition to diabetic foot ulcers, since the threat of amputation can be enhanced by these all the more.
Invokana Lawsuits in New Jersey MDL:
Invokana legal cases accusing the company of not being able to alert health professionals as well as patients of the possible dangers of using the medication have been submitted by 100s of affected individuals. Approximately 500 of those statements have been consolidated in the United States District Court of New Jersey which includes numerous alleged injuries such as general kidney damage ailments as well as a blood disorder called diabetic ketoacidosis.
How to Understand Whether You Do Have an Invokana Lawsuit?
As a matter of fact, without talking to an attorney you will probably be unable to know whether you do have an Invokana lawsuit. Lawyers who are knowledgeable in such claims will be able to advise you on whether you do have this type of claim.
In case you have experienced Invokana amputations, you will be guided by an attorney through the entire process who will also suggest you whether you do have a prospective lawsuit with merit.
Although the FDA has already been vocal on the amputation threat for this particular medication, a lawyer will be able to update you with the relevant info which you might not be capable of finding by yourself.